Application

This Anti-Integrin β3 Antibody, clone PM6/13 is validated for use in FC, IP, WB, IH, IH(P) for the detection of Integrin β3.

Research Sub CategoryIntegrins

FACS: As a marker for megakaryoblastic/cytic leukaemias and idiopathic thrombocythemia





Optimal working dilutions must be determined by the end user.

Research CategoryCell Structure

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Human platelet plasma membrane

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: MAB1381

Physical form

The monoclonal is presented at a concentration of 100µg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.

Format: Purified

Specificity

The antibody is specific for the 110 kDa platelet glycoprotein GP IIIa and inhibits platelet aggregation and activation induced by thrombin and collagen. The platelet glycoprotein is the integrin beta3 chain of the vitronectin receptor and GPIIb/IIIa. The antigen is present on platelets and megakaryocytes.

Antigen distribution:

Platelets >98%

Megakaryocytes >98%

Granulocytes 0%

Monocytes 0%

LGL cells 0%

B cells 0%

T cells 0%

Peripheral blood lymphocytes 0%

FUSION PARTNER: SP2/0 myeloma cell line

Storage and Stability

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.